MiCal is the missing calendar app that you’ve always wished your iPhone or iPad had! MiCal makes scheduling easier, clearer — and better looking — than ever before. MiCal presents events, appointments, reminders, birthdays, weather and many more. 1-844-44 MiCAL (64225) 1-844-446-4225. SERVING UPPER PENINSULA & OAKLAND COUNTY. Support for people in distress.
Mical Raz, MD, PhD, MSHP, completed her medical training at Tel Aviv University, from where she also received a PhD in history of medicine. Before moving to the US for a postdoctoral fellowship at Yale, she worked at the Tel Aviv Medical Center and volunteered with Physicians for Human Rights. She completed her residency in Internal Medicine at Yale New Haven Hospital in 2015, followed by a Robert Wood Johnson Clinical Scholars Fellowship at the University of Pennsylvania. She is also a practicing hospitalist at URMC at Strong Memorial Hospital, and is board certified in internal medicine.
She is the author of The Lobotomy Letters: The Making of American Psychosurgery (University of Rochester 2013), which was awarded the Pressman-Burroughs Wellcome Career Development Award. Her second book, What's Wrong with the Poor? Race, Psychiatry and the War on Poverty (UNC 2013), was a 2015 Choice Outstanding Academic Title. Her third book Abusive Policies: How the American Child Welfare System Lost its Way was published in late 2020. Her current interests including child welfare reform and the movement to abolish child protective services.
Selected Op-Eds and Popular Writing
- Raz M, “ Family Separation Doesn’t Just Happen at the Border,” Made By History, Washington Post, January 30, 2019. https://www.washingtonpost.com/outlook/2019/01/30/family-separation-doesnt-just-happen-border/
- Raz, M “What We Get Wrong About the Poverty Gap In Education,” Made by History, Washington Post, July 2, 2018. https://www.washingtonpost.com/news/made-by-history/wp/2018/07/02/what-we-get-wrong-about-the-poverty-gap-in-education/
- Raz, M “More Mandatory Reporting Won’t Keep Children Safe From Predators” Made by History, Washington Post, May 1 ,2018. https://www.washingtonpost.com/news/made-by-history/wp/2018/05/01/more-mandatory-reporting-wont-keep-children-safe-from-predators/
- Raz, M and Doroshow, D. “Wordsworth Case Shows it's Time to Rethink 'Treatment' for Juveniles, Philadelphia Inquirer, November 3, 2016. http://www.philly.com/philly/opinion/20161103_Commentary__Wordsworth_case_shows_it_s_time_to_rethink__treatment__for_juveniles.html
- Raz, M. “DHS Must Rethink Care of Children and Families”, Philadelphia Inquirer, September 16, 2016. http://www.philly.com/philly/opinion/20160916_Commentary__DHS_must_rethink_care_of_children_and_families.html
Graduate Research Fields
I offer the following fields for graduate research: History of Psychiatry, History of Public Health, Child Welfare. For more information on our MA and PhD programs, see our graduate program page.
I am accepting new graduate student advisees for our MA and PhD programs.
Courses Offered (subject to change)
- HIST 167M: Unequal, Unjust: 100 Years of Racism in American Public Health
- HIST 373W/473: Politics and Policies in the U.S. Health Care System, Syllabus
- PHLT 116: Introduction to the U.S. Health System, Syllabus
Selected Publication Covers
- Doroshow, D, Gambino M, and Raz, M, 'New Directions in the Historiography of Psychiatry,” Journal of the History of Medicine and Allied Sciences, 2019 Jan 1;74(1):57-84.
- Raz M. and Beatty, B., “Replacing the 'Word Gap' with Non-stigmatizing Approaches to Early Literacy and Language Building,” forthcoming, Pediatrics 2018;142(6), e20181992.
- Raz, M. “Psychiatrists and the Transformation of Juvenile Justice in Philadelphia, 1965-72”, Journal of the History of Medicine and Allied Sciences, 2018 Volume 73, Issue 4: 437–463.
- Raz, M. “Lessons from History: Parents Anonymous and Child Abuse Prevention Policy,” Pediatrics December, 2017, 140(6).
- Raz, M. “Unintended Consequences of Expanded Mandatory Reporting Laws,” Pediatrics, April 2017, 139 (4), 2016-3511.
- Raz, M. Treating Addiction or Reducing Crime? Methadone Maintenance and Drug Policy under the Nixon Administration, Journal of Policy History, 2017, 29(1): 58–86
- Raz, M. Deprived of Touch: How Maternal and Sensory Deprivation Theory Converged in Shaping Early Debates over Autism, History of the Human Sciences, 2014, 27(2): 75-96.
- Raz, M. The Deprivation Riots: Psychiatry as Politics in the 1960s, Harvard Review of Psychiatry, 2013, 21(6):345-50.
- Raz, Mical. The Lobotomy Letters: the Making of American Psychosurgery. Rochester, NY: University of Rochester Press, 2015. http://www.urpress.com/store/viewItem.asp?idProduct=14161
- Raz, Mical. Whats Wrong with the Poor?: Psychiatry, Race, and the War on Poverty. Place of publication not identified: Univ Of North Carolina Pr, 2016.
|PDB||Ortholog search: |
|List of PDB id codes|
|Aliases||MICAL1, MICAL, MICAL-1, NICAL, microtubule associated monooxygenase, calponin and LIM domain containing 1|
|External IDs||OMIM: 607129MGI: 2385847HomoloGene: 11246GeneCards: MICAL1|
|Gene location (Human)|
|Chr.||Chromosome 6 (human)|
|Gene location (Mouse)|
|Chr.||Chromosome 10 (mouse)|
|Band||10 10 B2||Start||41,476,314 bp|
|RNA expression pattern|
|More reference expression data|
|Molecular function||•SH3 domain binding|
•oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
•Rab GTPase binding
•GO:0001948 protein binding
•metal ion binding
•protein kinase binding
•NAD(P)H oxidase activity
•actin filament binding
•hippocampal mossy fiber expansion
|Biological process||•negative regulation of protein phosphorylation|
•actin filament depolymerization
•negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
•negative regulation of apoptotic process
•regulation of regulated secretory pathway
|Sources:Amigo / QuickGO|
|Location (UCSC)||Chr 6: 109.44 – 109.47 Mb||Chr 10: 41.48 – 41.49 Mb|
|View/Edit Human||View/Edit Mouse|
Blueprint product. NEDD9-interacting protein with calponin homology and LIM domains is a protein that in humans is encoded by the MICAL1gene.
MICAL1 has been shown to interact with NEDD9 and RAB1A.
- ^ abcGRCh38: Ensembl release 89: ENSG00000135596 - Ensembl, May 2017
- ^ abcGRCm38: Ensembl release 89: ENSMUSG00000019823 - Ensembl, May 2017
- ^'Human PubMed Reference:'. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^'Mouse PubMed Reference:'. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ abSuzuki T, Nakamoto T, Ogawa S, Seo S, Matsumura T, Tachibana K, Morimoto C, Hirai H (Apr 2002). 'MICAL, a novel CasL interacting molecule, associates with vimentin'. J Biol Chem. 277 (17): 14933–41. doi:10.1074/jbc.M111842200. PMID11827972.
- ^'Entrez Gene: MICAL1 microtubule associated monoxygenase, calponin and LIM domain containing 1'.
- ^Weide, Thomas; Teuber Julia; Bayer Michael; Barnekow Angelika (Jun 2003). 'MICAL-1 isoforms, novel rab1 interacting proteins'. Biochem. Biophys. Res. Commun. United States. 306 (1): 79–86. doi:10.1016/S0006-291X(03)00918-5. ISSN0006-291X. PMID12788069.
- Iwata S, Ohashi Y, Kamiguchi K, Morimoto C (2000). 'Beta 1-integrin-mediated cell signaling in T lymphocytes'. J. Dermatol. Sci. 23 (2): 75–86. doi:10.1016/S0923-1811(99)00096-1. PMID10808124.
- Maruyama K, Sugano S (1994). 'Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides'. Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). 'Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library'. Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
- Hattori A, Okumura K, Nagase T, et al. (2001). 'Characterization of long cDNA clones from human adult spleen'. DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID11214971.
- Terman JR, Mao T, Pasterkamp RJ, et al. (2002). 'MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion'. Cell. 109 (7): 887–900. doi:10.1016/S0092-8674(02)00794-8. PMID12110185.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). 'Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences'. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS..9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID12477932.
- Weide T, Teuber J, Bayer M, Barnekow A (2003). 'MICAL-1 isoforms, novel rab1 interacting proteins'. Biochem. Biophys. Res. Commun. 306 (1): 79–86. doi:10.1016/S0006-291X(03)00918-5. PMID12788069.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). 'The DNA sequence and analysis of human chromosome 6'. Nature. 425 (6960): 805–11. Bibcode:2003Natur.425.805M. doi:10.1038/nature02055. PMID14574404.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). 'Complete sequencing and characterization of 21,243 full-length human cDNAs'. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). 'The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)'. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID15489334.
- Fischer J, Weide T, Barnekow A (2005). 'The MICAL proteins and rab1: a possible link to the cytoskeleton?'. Biochem. Biophys. Res. Commun. 328 (2): 415–23. doi:10.1016/j.bbrc.2004.12.182. PMID15694364.
- Bayer M, Fischer J, Kremerskothen J, et al. (2006). 'Identification and characterization of Iporin as a novel interaction partner for rab1'. BMC Cell Biol. 6 (1): 15. doi:10.1186/1471-2121-6-15. PMC1079803. PMID15796781.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). 'Global, in vivo, and site-specific phosphorylation dynamics in signaling networks'. Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID17081983. S2CID7827573.
- Jin X, Zhang J, Dai H, et al. (2007). 'Investigation of the four cooperative unfolding units existing in the MICAL-1 CH domain'. Biophys. Chem. 129 (2–3): 269–78. doi:10.1016/j.bpc.2007.06.008. PMID17662518.
Retrieved from 'https://en.wikipedia.org/w/index.php?title=MICAL1&oldid=994304611'